Acronyms developed in the One True Thread for the comic include:
- GLR
- Great Lord Randall
- MMONS
- Massively Multiplayer Online Nerd Sniping
- np
- newpix
- NP
- NewPage, a page of the One True Thread
- OTA
- One True Author
- OTC
- One True Comic
- OTT
- One True Thread
- OTW
- One True Wiki
- PFANP
- Pope for a Newpage
- q
- cue (unit)